A range of reinforced concrete frame buildings with different levels of inelasticity as well as periods of vibration is analyzed to study the floor response. The derived floor acceleration response spectra are normalized by peak ground acceleration, peak floor acceleration, and ground response spectrum. The normalization with respect to ground response spectrum leads to the lowest coefficients of variation. Based on this observation as well as previous studies, an amplification function is proposed that can be used to develop design floor spectra from the ground motion spectrum, considering the building’s dynamic characteristics and level of inelasticity.